Toluene (Developmental)
Toluene is listed under California Proposition 65 for the Developmental endpoint. Its established safe harbor level is 7000 µg/day as a MADL, determined for exposure primarily via the inhalation route. CAS registry number: 108-88-3.
Safe Harbor Level
| Field | Value |
|---|---|
| Chemical | Toluene |
| CAS Number | 108-88-3 |
| Toxicity Endpoint | Developmental |
| Safe Harbor Basis | MADL |
| Safe Harbor Level | 7000 µg/day |
| Primary Exposure Route | Inhalation |
What this level means
A MADL is a daily exposure level for Toluene that — at or below 7000 µg/day per day — does not require a Proposition 65 warning because it poses no significant risk for the Developmental endpoint. This is the Maximum Allowable Dose Level (MADL) — the daily intake for the reproductive/developmental endpoint.
- Level: 7000 µg/day per day (MADL).
- Endpoint: Developmental.
- Route: exposure is assessed primarily through the inhalation route.
- CAS: 108-88-3.
Businesses that expose consumers to more than the safe harbor level for Toluene must provide a clear and reasonable Prop 65 warning. Compliance is assessed against the applicable OEHHA safe harbor level above; where no safe harbor level is established, an exposure assessment may be required.
Compliance notes
- Compare the daily exposure to the MADL of 7000 µg/day.
- If exposure exceeds the level, a Prop 65 warning is generally required.
- Confirm the current OEHHA listing and any updates to the level before relying on it — safe harbor levels are amended periodically.
Frequently Asked Questions
What is the Prop 65 safe harbor level for Toluene?
7000 µg/day per day (MADL).
What is the CAS number for Toluene?
108-88-3.
What endpoint is Toluene listed for?
Developmental.
What is the primary route of exposure for Toluene?
The inhalation route.
What is the difference between an NSRL and a MADL?
An NSRL (No Significant Risk Level) applies to cancer endpoints; a MADL (Maximum Allowable Dose Level) applies to reproductive and developmental endpoints.